Update Of nCoV With Hope In Anti-Viral Drugs
Dear Friends & Neighbors,
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As of Wednesday, February 5, 2020, based on John Hopkins University global information about the number of confirmed cases and deaths, there are 494 deaths, 1,029 recovered, out of 24,631 confirmed cases of infection. Testing of the anti-viral drugs for treating Coronavirus, pneumonia, and lung diseases historically had been done by CDC, but now will also be distributed to local labs so to be tested on a regular basis.
In a letter to the editor in the video below, the authors of the study tested a total of five FDA-approved medications for potentially treating 2019 nCoV, Remdesivir, and chloroquine, were some of the drugs that were highly effective against the novel coronavirus (aka 2019-nCoV) in vitro. In the wikipedia page, lopinavir/ritonavir were also mentioned to have fairly good inhibitory effects on 2019 nCov at the cellular level. Further randomized, placebo-controlled tests/studies are needed to confirm the efficacy of these drugs.
Remdesivir works in vitro in Ebola, SARS, and MERS patients in vitro but not in vivo (in real patients) and now is being tried on 2019 nCoV patients and appears to be working. Its mechanism is explained in the video below. Excerpt from wikipedia about Remdesivir, in italics, below:
In response to the 2019–20 Wuhan coronavirus outbreak induced by the coronavirus 2019-nCoV, Gilead provided remdesivir for a “small number of patients” in collaboration with Chinese medical authorities for studying its effects.  Gilead also started laboratory testing of remdesivir against 2019-nCoV. Gilead stated that remdesivir was “shown to be active” against SARS and MERS in animals. In late January 2020, Chinese medical researchers stated to the media that in exploratory research considering a selection of 30 drug candidates, three of them, remdesivir, chloroquine and lopinavir/ritonavir, seemed to have “fairly good inhibitory effects” on 2019-nCoV at the cellular level. Requests to start clinical testing were submitted.
The drug was administered to the first US patient to be confirmed to be infected by 2019-nCoV for “compassionate use” after he progressed to pneumonia.
In the video “REMDESIVIR IS THE CORONA CURE? Bio Inc #3“, aired on 2/5/2020, below:
In the video of Feb. 1, 2020, with more optimistic outlook, in Mandarin, below:
In the video with reports of much discontent and criticisms of many problems, in Mandarin, below:
In the video “Coronavirus clinical trials with Remdesivir by Dr. Paul Cottrell“, below:
Chloroquine has been around a long time to treat malaria also appears to work by raising the PH level of the lysosome to preventing merging. mechanism also explained in the video below. Excerpt from wikipedia about Chloroquine, in italics, below:
Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. It is also occasionally used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus. It is taken by mouth.
Common side effects include muscle problems, loss of appetite, diarrhea, and skin rash. Serious side effects include problems with vision, muscle damage, seizures, and low blood cell levels. It appears to be safe for use during pregnancy. Chloroquine is a member of the drug class 4-aminoquinoline. It works against the asexual form of malaria inside the red blood cell.
Chloroquine was discovered in 1934 by Hans Andersag. It is on the World Health Organization’s List of Essential Medicines, the safest and most effective medicines needed in a health system. It is available as a generic medication. The wholesale cost in the developing world is about US$0.04. In the United States, it costs about US$5.30 per dose.
Lopinavir/ritonavir are not discussed in the video below but had also been tried, with excerpt from Wikipedia, in italics, below:
Lopinavir/ritonavir (LPV/r), sold under the brand name Kaletra among others, is a fixed dose combination medication for the treatment and prevention of HIV/AIDS. It combines lopinavir with a low dose of ritonavir. It is generally recommended for use with other antiretrovirals. It may be used for prevention after a needlestick injury or other potential exposure. It is taken by mouth as a tablet, capsule, or solution.
Common side effects include diarrhea, vomiting, feeling tired, headaches, and muscle pains. Severe side effects may include pancreatitis, liver problems, and high blood sugar. It is commonly used in pregnancy and it appears to be safe. Both medications are HIV protease inhibitors. Ritonavir functions by slowing down the breakdown of lopinavir.
Lopinavir/ritonavir as a single medication was approved for use in the United States in 2000. It is on the World Health Organization’s List of Essential Medicines, the safest and most effective medicines needed in a health system. The wholesale cost in the developing world is 18.96 to 113.52 a month. In the United States it is not available as a generic medication and costs more than US$200 for a typical month supply as of 2016.
Coronavirus epidemic update 11 by pulmonologist Dr. Seheult of https://www.MedCram.com
This video illustrates how antiviral medications work, how antivirals may be used for treatment before effectiveness has been demonstrated by clinical trials (compassionate use), and the recent in vitro results of testing of a variety of antiviral medications that was published in the journal Nature. Dr. Seheult also provides updates on the latest novel Wuhan coronavirus news (2019-nCoV) including expanded coronavirus testing in the US as directed by the CDC, the Diamond Princess quarantine in Japan, and other recent coronavirus data, in the video “Coronavirus Epidemic Update 11: Antiviral Drugs, Treatment Trials for nCoV (Remdesivir, Chloroquine)“, below:
Asia, the Pacific, and Nonproliferation Subcommittee holds a hearing on the Wuhan coronavirus outbreak and its implications. The new coronavirus has now killed at least 490 people and infected about 24,000 worldwide, in the video “WATCH LIVE: House hearing on assessing coronavirus outbreak and response – 2/5/2020“, below:
A video of what is like in Wuhan, aired 1/28/2020, below:
Chinese researchers and epidemiologists have concluded that the novel 2019 nCoV did not begin in one area of seafood market but from multiple areas.
For individuals and home preparation for in case you need to self-quarantine to protect yourself and others :
- Washing your hands frequently with soap after using bathroom and before preparing for food
- Avoid social contacts
- Staying home when sick
- Businesses, schools, organizations may want to consider how to conduct business via telecommute or online or some other forms rather than person-to-person contact
- Staying at least 6 feet away from some one showing signs and symptoms
- Have few months’ supply of your prescription medications
- Stock up on commonly used over the counter medications such as cough suppressants, antibiotic ointments and creams, Imodium AD, etc.
- Prepare for the possibility that you may need to quarantine a sick friend or family member inside your home & be able to clean and disinfect the space where you and possibly multiple others will be living for extended period
- Protective equipment (masks, tyvex full body suits, disposable gloves)
- Few months of supply of food (canned goods, dehydrated food, beans, rice, etc.)
- Access to clean water (activated carbon filter water pitcher or distiller)
- HEPA air filter (helps to clean out bacteria, virus, fungi in the air)
- Oxygen concentrator (in case one’s respiratory system is compromised and have difficulty in obtaining help from healthcare providers.)
- Practice qigong, tai chi, yoga, or whatever would help to keep you calm and optimistic
Gathered, written, and posted by Windermere Sun-Susan Sun Nunamaker More about the community at www.WindermereSun.com
~Let’s Help One Another~
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